Table 5.
Incidence and reason of discontinuation according to treatment group
| Variable | All patients | Age (years) | ||
|---|---|---|---|---|
| A | B | C | ||
| n | 132 | 55 | 53 | 24 |
| Discontinuation | 28 (21) | 5 (9) | 14 (26) | 9 (38) |
| Adverse events | 14 (11) | 2 (4) | 8 (15) | 4 (17) |
| Fatigue | 4 | 0 | 1 | 3 |
| Depression | 2 | 1 | 1 | 0 |
| Arthralgia | 2 | 0 | 2 | 0 |
| Arrhythmia | 2 | 0 | 1 | 1 |
| Pyrexia | 1 | 1 | 0 | 0 |
| Headache | 1 | 0 | 1 | 0 |
| Hyperthyroidism | 1 | 0 | 1 | 0 |
| Colon cancer | 1 | 0 | 1 | 0 |
| Laboratory abnormality | 4 (3) | 1 (2) | 1 (2) | 2 (8) |
| High aminotransferase | 2 | 1 | 0 | 1 |
| Anemia | 1 | 0 | 1 | 0 |
| Neutropenia | 1 | 0 | 0 | 1 |
| Refusal of treatment | 3 (2) | 1 (2) | 1 (2) | 1 (4) |
| Insufficient response | 2 (2) | 0 | 1 (2) | 1 (4) |
| Failure to return | 5 (4) | 1 (2) | 3 (6) | 1 (4) |
Data are number of patients (percentage in each patient group)