Fig. 6.

Schema showing the interactions between cholesterol metabolism-associated factors. Arrows (⇑ and ⇓) represent significant difference in expression levels between PBC patients and normal controls. LDLR LDL receptor, SREBP sterol regulatory element-binding protein, NPC1L1 Niemann-Pick C1 like 1, ApoB apolipoprotein B, MTP microsomal triglyceride protein, ABCG5/G8 ATP-binding cassette G5/G8, LXRα liver X receptor α, CYP7A1 cholesterol 7α-hydroxylase, FXR farnesoid X receptor, BSEP bile salt export pump, PPARα peroxisome proliferator-activated receptor α, MDR3 multidrug resistance 3