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. Author manuscript; available in PMC: 2010 Jun 1.
Published in final edited form as: J Immunol. 2009 Jun 1;182(11):6744–6752. doi: 10.4049/jimmunol.0804387

Figure 6.

Figure 6

Adoptive transfer of Bcl-xL and Survivin transduced CD8+ T cells into tumor-bearing mice augments mouse survival. Naïve CD8+ T cells from OT-I TCR transgenic mice were stimulated with APCs/peptide. On day 2/3, T cells were transduced with retroviral vectors expressing GFP, GFP with Bcl-xL, GFP with Survivin, or GFP with Bcl-xL and Survivin. On day 5 of primary culture, GFP+ CD8+ T cells were sorted and adoptively transferred into naive recipient mice that were subsequently challenged i.p. with EG.7 (a) or EL4 (b) tumor cells. Percent survival was studied for 50 days. Kaplan Meier survival analysis indicated significantly increased survival in mice (n=6) receiving Bcl-xL and Survivin transduced CD8+ T cells compared to control groups (log rank test, P<0.05).