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. Author manuscript; available in PMC: 2009 Sep 22.
Published in final edited form as: Best Pract Res Clin Haematol. 2007 Mar;20(1):19–27. doi: 10.1016/j.beha.2006.11.001

Figure 1.

Figure 1

Interactions in the endosteal niche.

This cartoon represents the functional elements of the endosteal niche. It remains controversial as to whether the stem cell resides in immediate contact with osteoblasts or whether the endosteal surface is a more important site of location than the perivascular regions in the bone marrow. However, functional studies have indicated that certain elements of bone are important in regulating stem cells as shown here.