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. Author manuscript; available in PMC: 2009 Sep 22.
Published in final edited form as: Cancer Cell. 2007 Jan;11(1):83–95. doi: 10.1016/j.ccr.2006.11.021

Figure 1. Design of Clinical Trial and Target Validation by Immunohistochemistry.

Figure 1

(A) Trial schema. Dots indicate time points of data collection. AZD2171 was administered during the period shaded red.

(B) Representative immunohistochemistry of glioblastoma endothelium. As expected, VEGFR2 and PDGFRα are expressed in the endothelial cells. Interestingly, PDGFRβ is also highly expressed in endothelial cells. (Bar represents 100 μm for all images.)