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. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: Nat Rev Neurosci. 2008 Sep 11;9(10):788–796. doi: 10.1038/nrn2345

Figure 3. Changes in BOLD signal in response to cognitive and emotional tasks associated with cognitive therapy.

Figure 3

Nine depressed participants and 24 controls completed tasks that involved rating the personal relevance of negative words and arranging digits in numerical order before and after 12 weeks of cognitive therapy (CT). As shown in the figure, CT was associated with normalization of amygdala activity in response to emotional words as well as normalization of dorso-lateral prefrontal activity during a cognitive task that involved putting digits in numerical order in working memory.91