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. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: Nat Rev Neurosci. 2008 Sep 11;9(10):788–796. doi: 10.1038/nrn2345

Figure 4. Hypothetical time-course of changes to amygdala and prefrontal function associated with ADM and CT.

Figure 4

A. During acute depression, amygdala activity is increased (red) and prefrontal activity is decreased (blue) compared to healthy individuals; B. CT effectively exercises the PFC, yielding increased inhibitory function; C. ADM targets amygdala function more directly, decreasing its activity; D. After ADM or CT, amygdala function is decreased and prefrontal function is increased. The double-headed arrow between the amygdala and PFC represents the bidirectional homeostatic influences which are believed to operate in healthy individuals.