Skip to main content
. Author manuscript; available in PMC: 2009 Sep 22.
Published in final edited form as: Curr Opin Hematol. 2008 Jul;15(4):381–390. doi: 10.1097/MOH.0b013e328302c7df

Figure 4. BCL6 regulates different biological functions through distinct corepressors.

Figure 4

A: The graphical representation depicts two molecules of BCL6 forming a homodimer through the BTB domain. The BCL6 BTB domain can recruit SMRT, N-CoR and BCoR through the lateral groove. Repression of ATR, CHEK1, TP53 and CDKN1A is dependent on these corepressors and mediates survival and proliferation during AID induced somatic hypermutation. A region of BCL6 proximal to the BTB domain recruits CtBP, which can mediate negative autoregulation of BCL6. The central second repression domain (RD2) of BCL6 recruits an MTA3/NuRD complex, which is required for repression of PRDM1 and thus mediates differentiation blockade. The zinc finger (ZF) domain can bind directly to ETO [52], although a specific biological function for this corepressor is not yet known. B: A gene ontology analysis of BCL6 target genes identified by ChIP-on-chip shows them to be associated with specific biological functions as indicated in the pie chart.