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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Drug Alcohol Depend. 2009 Jul 10;104(Suppl 1):S64–S69. doi: 10.1016/j.drugalcdep.2009.06.003

Figure 3. Genetic Association on Chromosome 15 with Nicotine Dependence.

Figure 3

The top line represents the region on chromosome 15 from 76,510,000 through 76,730,000 base pairs. The second and third lines signify the genes in this chromosomal location (IREB2, LOC123688, PSMA4, CHRNA5, CHRNA3, and CHRNB4) and gene transcripts. The fourth line represents the genetic variants associated with nicotine dependence identified by rs16969968 and the correlated variants (r2 > 0.8). The fifth line identifies the genetic variants associated with nicotine dependence identified by rs578776 and correlated variants (r2 > 0.8). Studies that have identified as association with nicotine dependence and correlated smoking characteristics are noted.