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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: J Mol Neurosci. 2008 May 29;36(1-3):292–298. doi: 10.1007/s12031-008-9086-2

Figure 4. PKA and MAPK/ERK kinase signaling cascades contribute to the PACAP-induced increase in neuronal excitability.

Figure 4

Excitability curves summarize the effects of the PKA inhibitor H-89 and the MEK kinase inhibitor PD 98059 on the PACAP induced change in neuronal firing. Both H-89 and PD 98059 significantly blunted the PACAP effect on neuronal excitability. Data are plotted as the mean number of action potentials generated with a 1 second depolarizing current pulse at multiple stimulus intensities. Error bars show SEM. Data points for each treatment were fit by linear regression and the difference in slope between treatments was analyzed. Treatments were done separately in multiple preparations.