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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: J Mol Neurosci. 2008 May 29;36(1-3):292–298. doi: 10.1007/s12031-008-9086-2

Figure 5. A rise in cAMP alone does not recapitulate the PACAP effect on excitability.

Figure 5

Increasing cAMP levels by treatment with either the adenylyl cyclase activator forskolin or the cell permeable cAMP analog 8-bromo-cAMP did not increase neural excitability to the level produced by PACAP. Data are plotted as the mean number of action potentials generated with a 1 second depolarizing current pulse at multiple stimulus intensities. Error bars show SEM. Data points for each treatment were fit by linear regression and the slopes were compared.