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. Author manuscript; available in PMC: 2009 Sep 22.
Published in final edited form as: Drug Discov Today. 2007 Apr 26;12(11-12):440–445. doi: 10.1016/j.drudis.2007.04.006

Figure 2. Orphan nuclear receptor TLX.

Figure 2

(a) Structure/function domains and sequence homology of human (h), mouse (m) TLX, and Drosophila Tailless (dTLL). b A model of TLX-mediated neural stem cell (NSC) maintenance and self-renewal. TLX stimulates NSC proliferation and self-renewal and inhibits NSC differentiation to maintain NSCs in the undifferentiated and self-renewable state. Ligands of TLX can modulate these events through regulating TLX activity.