Table 3.

Association Between Baseline Homocysteine, Vitamin Treatment, and Cognitive Outcomes in Adjusted Models Using Multiple Regression^*

	Baseline Homocysteine (μmol/L)†		Vitamin Treatment‡
Cognitive Outcome	Regression coefficient (SE)	P value	Regression coefficient (SE)	P value
TICSm	-.05 (.02)	.04	-.28 (.34)	0.4
Cognitive composite	-.00 (.00)	.4	-.01 (.05)	0.9
Memory composite	-.00 (.00)	.6	-.02 (.06)	0.7

Note: Homocysteine reported in umol/L, unit for conversion to mg/L, x0.135. Cognitive composite = Cognitive z-score composite composed of TICSm totals score, digit span forward and backward span scores, and verbal fluency total correct. Memory composite = Memory composite composed of TICSm word list immediate and delayed recall, and the recognition trials.

Abbreviations: TICSm = Telephone Interview of Cognitive Status – modified, SE = standard error

^*Models adjusted for the following variables collected at HOST baseline: age, education, race, kidney disease status (advanced chronic kidney disease, end-stage renal disease), cardiovascular disease, diabetes, systolic and diastolic blood pressure, hypertension treatment, and plasma total homocysteine. Geriatric Depression Scale score at the time of cognitive testing was also included in the model.

^†Values at baseline of parent VA Homocysteine Study.

^‡Effect of vitamin treatment compared with placebo.