Table 4.
Adjusted analysis for hip and lumbar spine bone mineral density
| Total hip BMD as outcome | Lumbar spine BMD as outcome | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Partial model | Full model | Partial Model | Full Model A | Full Model B | ||||||
| Variables | Parameter estimate |
P value | Parameter estimate |
P-value | Parameter estimate |
P-value | Parameter estimate |
P- value |
Parameter estimate |
P- value |
| Erosion score* | −0.0047 | 0.070 | −0.0044 | 0.10 | 0.00007 | 0.9 | −0.0017 | 0.6 | −0.0068 | 0.13 |
| Age, per decade* | −0.0038 | 0.0001 | −0.0040 | 0.0001 | −0.0012 | 0.4 | −0.0023 | 0.1 | −0.0020 | 0.9 |
| Body mass index* | 0.0073 | <0.0001 | 0.0069 | < 0.001 | 0.0052 | 0.006 | 0.0040 | 0.05 | 0.0044 | 0.10 |
| Cumulative oral GC dose* | −0.0000011 | 0.17 | −0.0000008 | 0.34 | 0.0000002 | 0.9 | −0.0000003 | 0.6 | −0.00058 | 0.6 |
| Prior fragility fracture | --- | --- | −0.046 | 0.17 | --- | --- | --- | --- | --- | --- |
| DMARD use, ever | --- | --- | --- | --- | --- | --- | 0.055 | 0.06 | 0.075 | 0.04 |
| Prior BIS use | --- | --- | −0.05 | 0.03 | --- | --- | --- | --- | --- | --- |
| Prior non-BIS use | --- | --- | 0.03 | 0.02 | --- | --- | --- | --- | --- | --- |
| CRP, per one unit increase | --- | --- | --- | --- | --- | --- | --- | --- | 0.0032 | 0.03 |
N = 144 for lumbar spine model and 152 for total hip model. GC, glucocorticoids; DMARD, disease-modifying antirheumatic drugs. BIS, bisphosphonate.
*
Variables forced into all models. In the full model, all variables listed in Table 1 were tested for entry and remained if the p-value < 0.2. The difference in months between the date of DXA and hand x-ray was controlled for in the partially and fully adjusted models. Full Model A includes all patients with lumbar spine BMD measurements. Full Model B excludes any woman whose DXA scan was limited by osteoarthritis or a fracture.