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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: J Comb Chem. 2009 Sep–Oct;11(5):851–859. doi: 10.1021/cc9000532

Scheme 8.

Scheme 8

Synthesis of 1H-imidazoles 19a

aReagents and conditions: (i) ammonium acetate, acetic acid, 100 °C, overnight; (ii) KOTMS, THF, 1 h; (iii) mesyl chloride, pyridine, 1 h; (iv) 50% TFA in DCM, 1 h