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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: J Comb Chem. 2009 Sep–Oct;11(5):851–859. doi: 10.1021/cc9000532

Scheme 10.

Scheme 10

Synthesis of 2H-isoquinolin-1-ones 23a

aReagents and conditions: (i) 2-carboxybenzaldehydes (2 equiv.), DIC (1 equiv.), DMF, overnight; (ii) DBU, DMF, 30 min; (iii) 50% TFA, DCM, 1 h