Fig. 2.
Percent control activity (PCA) at 20 μg/mL for compounds 1–13 isolated from Brassaiopsis glomerulata in the noncellular, enzyme-based aromatase bioassay and in SK-BR-3 hormone-independent human breast cancer cells that overexpress aromatase (DMSO = dimethyl sulfoxide, blank/negative control; AG = aminoglutethimide, positive control in noncellular assay, 50 μM; LET = letrozole, positive control in cell-based assay, 10 nM). Each bar represents the mean and standard error of three replicates, with statistically significant differences indicated in the non-cellular assay by different numbers of stars and in the cell-based assay by different letters (P < 0.0001).
