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. Author manuscript; available in PMC: 2009 Sep 22.
Published in final edited form as: Nature. 2007 Oct 18;449(7164):919–922. doi: 10.1038/nature06205

Figure 2. IFNβ-induced miRNAs display anti-viral activity against HCV.

Figure 2

a, JFH1-replicon-containing Huh7 cells were transfected with single non-specific miRNA-mimics (miR-ctrl), a pool of control miRNAs (miR-ctrl(mix5)) or anti-miRNAs (anti-miR-ctrl), or specific miRNA-mimics corresponding to the eight IFNβ-induced miRNAs, or specific anti-miRNAs. In addition, a combination of the five miRNAs that displayed anti-viral activity individually was used (miR-mix5) with or without anti-miR-122, as indicated, and HCV RNA was quantified by qPCR after 48 h. b, Same as a, except Huh7 cells were infected with live JFH-1 virus for 48 h (error bars, means ± s.d. of at least four independent experiments; P values are from paired Student’s t-tests).