(A) Origin and distribution of central noradrenergic pathways in the rat brain. Note noradrenergic cell groups A1–A7, including the locus coeruleus (A6). Modified with permission from Robbins and Everitt (1995). PFC, prefrontal cortex; Sept, septum; NAc, nucleus accumbens; MFB, medial fore-brain bundle; Hypo, hypothalamus; DNAB, dorsal noradrenergic ascending bundle; VNAB, ventral noradrenergic ascending bundle; CTT, central tegmental tract.
(B) Role of norepinephrine in dependence.