Fig. 4.
Effect of repeated, 7-day s.c. pretreatment (−15 min) with the selective sigma-1 receptor (Sig-1R) antagonist NE-100 on 3- (a, c, e) and 24-h (b, d, f) intake of alcohol (a and b), water (c and d), and food (e and f), relative to dark cycle onset in sP rats (N=9–10/group), tested under continuous access (24-h) conditions. Data represent mean±SEM intake, normalized for body weight. *P<0.05, **P<0.01, ***P<0.001 vs. vehicle-treated group (Student’s t tests)