Table 1.

Effect of acute s.c. pretreatment (−15 min) with the selective sigma-1 receptor (Sig-1R) antagonist NE-100 on blood alcohol levels 15, 30, 60, and 120 min following gavage administration of ethanol (1 g/kg, p.o.) to sP rats (n=8/group)

	15 min	30 min	60 min	120 min
Vehicle	67.5±14.2	104.2±4.4	93.2±5.4	66.4±7.4
NE-100, 30 mg/kg	59.4±12.3	100.6±8.6	85.5±9.2	58.5±6.5

Data represent the mean±SEM of mg of alcohol per deciliter of plasma.