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. Author manuscript; available in PMC: 2009 Sep 22.
Published in final edited form as: Neuropsychopharmacology. 2006 Oct 4;32(5):1052–1068. doi: 10.1038/sj.npp.1301214

Figure 1.

Figure 1

Effect of lateral ventricle (LV) pretreatment (−20 min) with murine urocortin 3 (Ucn 3) on mean (+ SEM) incremental food (a) and water intake (b) in nondeprived, male Wistar rats (n = 8) housed in automated test cages that detect intake as nosepoke events (Experiment 1). Food intake is normalized for body weight per Kleiber’s mass exponent. *p < 0.05 vs vehicle treatment (within-subject Newman–Keuls test). Panel (c) shows effects of LV injection of Ucn 3 on the formation of a conditioned taste aversion (CTA) (Experiment 2). Data are expressed as the mean (+ SEM) preference ratio for a 7.31mM saccharin solution over water as a function of having received LV Ucn 3 injections immediately after consuming the previously novel saccharin solution, §p < 0.05, post-pair preference ratios were significantly higher than pre-pair preference ratios (n = 7/group). Panel (d) shows effects of post-saccharin injections of the positive control 0.15M LiCl (i.p., 20 ml/kg) on the formation of a CTA for the otherwise palatable saccharin solution, as compared to rats receiving isotonic NaCl. LiCl, but not anorectic and hypodipsic doses of Ucn 3, reliably produced a conditioned taste aversion. *p < 0.05 vs NaCl injection, #p < 0.05 preconditioning (pre-pair) vs post-pairing (post-pair) preference ratio was significantly lower after LiCl injections, §p < 0.05, post-pair preference ratios were significantly higher than pre-pair preference ratios after NaCl injections (n = 7/group) (between-subject Newman–Keuls tests).