FIGURE 3.

Kinetics of Histoplasma capsulatum induced histopathology in the lung. A, Photomicrographs shown are of thin lung sections at days 5, 7, 10, 14, and 50 after infection of C57BL/6 mice. H&E-stained sections are shown at ×40 (top row) and ×400 (middle row) total magnification, and GMS stain is shown at ×400 total magnification (bottom row). Yeasts are indicated by arrows. B, Lung lesion size was measured as in Fig. 2. Data represent the average ± SEM from three mice per group. Granuloma burden was not quantified because less than one granuloma per field was observed. No more than three granulomas per lobe cross-section were observed.