Table 2.
VDR expression characteristics of the biopsies, stratified by the histology
| Normal, n (%) |
Metaplasia, n (%) |
Dysplasia, n (%) |
Bronchoscopy-detected cancers, n (%) |
Squamous cell carcinoma TMA, n (%) |
Adenocarcinoma TMA, n (%) |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Nuclear | Cytoplasmic | Nuclear | Cytoplasmic | Nuclear | Cytoplasmic | Nuclear | Cytoplasmic | Nuclear | Cytoplasmic | Nuclear | Cytoplasmic | |
| Intensity | ||||||||||||
| 0 | 17 (19) | 15 (17) | 15 (23) | 13 (20) | 3 (17) | 10 (23) | — | — | 3 (17) | 5 (28) | 28 (64) | 10 (59) |
| 1 | 18 (21) | 25 (29) | 10 (16) | 16 (24) | 6 (33) | 14 (32) | — | — | 7 (39) | 9 (50) | 8 (18) | 3 (18) |
| 2 | 50 (57) | 46 (53) | 33 (52) | 37 (56) | 9 (50) | 20 (46) | 3 (75) | 3 (75) | 8 (44) | 4 (22) | 8 (18) | 4 (24) |
| 3 | 3 (3) | 1 (1) | 6 (9) | — | — | — | 1 (25) | 1 (25) | — | — | — | |
| Percentage of cells (%) | ||||||||||||
| 0 | 17 (19) | 15 (17) | 15 (23) | 13 (20) | 4 (21) | 10 (23) | — | — | — | 5 (28) | 28 (64) | 12 (63) |
| <10 | 3 (3) | 7 (8) | 4 (6) | 2 (3) | — | — | — | — | 3 (17) | — | 1 (2) | — |
| 10–50 | 16 (18) | 12 (14) | 12 (19) | 14 (22) | 1 (5) | 4 (9) | — | 1 (25) | 5 (28) | 3 (17) | 5 (11) | 1 (5) |
| >50 | 51 (59) | 53 (61) | 33 (52) | 36 (55) | 14 (74) | 30 (68) | 4 (100) | 3 (75) | 10 (56) | 10 (56) | 10 (23) | 6 (32) |
| Distribution | ||||||||||||
| No staining | 17 (21) | 15 (18) | 15 (25) | 13 (21) | 3 (21) | — | — | — | 3 (18) | 5 (28) | — | 10 (59) |
| Basal | 2 (2) | 5 (6) | 2 (3) | 1 (2) | — | — | — | — | 1 (6) | 0 | — | — |
| Suprabasal | 19 (23) | 17 (20) | 8 (14) | 17 (28) | 2 (14) | — | — | — | 1 (6) | 1 (6) | — | 3 (18) |
| Full | 44 (54) | 46 (55) | 34 (58) | 30 (49) | 9 (64) | — | 2 (100) | 2 (100) | 12 (71) | 12 (67) | — | 4 (24) |
| Cytoplasmic vs nuclear intensity | ||||||||||||
| Nuclear > cytoplasmic | 25 (29) | 22 (34) | 7 (39) | 9 (53) | 30 (68) | |||||||
| Equal | 38 (44) | 26 (41) | 8 (44) | 4 (100) | 4 (24) | 5 (11) | ||||||
| Cytoplasmic > nuclear | 24 (29) | 16 (25) | 3 (17) | 4 (24) | 9 (21) | |||||||
Abbreviation: TMA, tumor microarray.