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. 2009 Jul 20;18(20):3805–3821. doi: 10.1093/hmg/ddp324

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© 2009 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — NIPA1 promotes traffic of BMPRII to a lysosomal compartment in neuronal cells. (A and B) Wild-type NSC34 cells (A) or NSC34 cells stably expressing NIPA1-GFP (B) were transiently transfected with myc-BMPRII and labelled with the lysosomal marker Lamp1. Note the appearance of strong co-localization between BMPRII and Lamp1 in the NIPA1-GFP-expressing cell. Arrows indicate selected individual vesicles that show co-localization. (C) Count of vesicles doubly positive for myc-BMPRII and Lamp1 in wild-type NSC34 cells (32 cells) or stably expressing NIPA1-GFP (35 cells). Note the increase in the number of puncta showing co-localization between Lamp1 and myc-BMPRII in the NIPA1-stable cells. Error bars: SEM. P-value was calculated using unpaired t-test.