Table 2.

Summary of experimental results

Human L1-CAM mutation	Protein domain affected	Amino acid change	Homophilic S2 cell aggregation	Adhesion-depend, EGFR activation in S2 cells	Protein expression in vivo	Cell surface expression in vivo	Genetic rescue of BM axonal pathfinding defect
Wild-type			wt	wt	wt	wt	Rescue
H1	Fn 5	Y1070C	wt	Reduced	wt	wt	No rescue
H38	Ig3	E309K	wt	Reduced	<wt	Partially intracellular	No rescue