Table 1.
mRNA expression of microglial and neuronal markers between Tg2576 mice and age-matched littermates, and between PBS vehicle-injected Tg256 mice and anti-GM-CSF antibody-injected Tg2576 mice (β-actin normalization)
| Marker | mRNA fold-change difference between 10-month-old Tg2576 mice and 10-month-old non-transgenic littermates | mRNA fold-change difference between 10-month-old PBS-injected Tg2576 mice and anti-GM-CSF antibody-injected 10-month-old Tg2576 mice |
|---|---|---|
| TNFα | 0.68 | 0.44 |
| IL1β | 2.24 | 0.26 |
| IL6 | 4.70 | 0.05 |
| Gp91 | 0.40 | 1.47 |
| CD11b | 1.20 | 0.11 |
| CD11c | 4.02 | 1.48 |
| CD40 | 1.39 | 0.31 |
| CD45 | 0.90 | 0.56 |
| MHCII -2 | 0.45 | 2.12 |
| GFAP | 1.30 | 1.64 |
| NeuN | 1.14 | 1.43 |
One-fold mRNA expression means no change between Tg2576 mice and non-transgenic littermates, and between PBS vehicle-injected Tg2576 mice and anti-GM-CSF antibody-injected Tg2576 mice; >1-fold mRNA expression indicates increased abundance to control mice and <1-fold mRNA expression, decreased abundance to control mice.