Table 2.

Summary of beta amyloid levels between PBS vehicle-injected Tg256 mice and anti-GM-CSF antibody-injected Tg2576 mice using sandwich ELISA

Number of mice	Soluble Aβ1-40 (pg/mg), mean ± SE	P-value	%Difference	Soluble Aβ1-42 (pg/mg), mean ± SE	P-value	%Difference	Insoluble Aβ1-40 (pg/mg), mean ± SE	P-value	%Difference	Insoluble Aβ1-42 (pg/mg), mean ± SE	P-value	%Difference
Tg2576 (n = 5)	6.4 ± 1.79	0.44	23% increased in anti-GM-CSF-injected mice	5.4 ± 1.1	0.28	46% decreased in anti-GM-CSF-injected mice	0.6 ± 0.11	0.18	27% increased in anti-GM-CSF-injected mice	0.28 ± 0.09	0.9	No change
Tg2576+anti-GM-CSF antibody (n = 5)	8.3 ± 1.33			3.7 ± 0.9			0.8 ± 0.06			0.27 ± 1.5

We found increased levels of soluble Aβ1-40 (23%, P < 0.44) and insoluble Aβ1-40 (27%, P < 0.18) in Tg2576 mice injected with anti-GM-CSF antibody compared with Tg2576 mice injected with PBS (control). However, these increased levels are not statistically significant may be because of small sample size (n = 5 in each group).

Interestingly, we also found decreased levels of soluble Aβ1-42 (46%, P < 0.28) in Tg2576 mice injected with anti-GM-CSF antibody compared with Tg2576 mice injected with PBS (control). However, these increased levels are not statistically significant.