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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: Cancer Res. 2008 Nov 1;68(21):9070–9077. doi: 10.1158/0008-5472.CAN-08-2328

Figure 2.

Figure 2

PSMA expression promotes cancer formation in mouse prostate recombinants. Paraffin embedded tissue recombinants grafted for a total of 8, 16 and 24 weeks were stained with either CK14 or E-cadherin. A pathologist (Dr. A Parwani) graded all specimens in blinded fashion. Arrows point to small atypical glands that lack CK-14 (basal cell) expression and display aberrant E-cadherin expression. These prostate glands display features of carcinoma similar to that of human prostate adenocarcinoma. Only PSMA-transgenic tissue recombinants were observed to display these small atypical glands with features of adenocarcinoma. Wild-type tissue recombinants displayed PINlike lesions that have strong CK14- and membrane E-cadherin expressions. Photomicrographs were captured at 40× magnification.