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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: Cancer Res. 2008 Nov 1;68(21):9070–9077. doi: 10.1158/0008-5472.CAN-08-2328

Table 2.

PSMA expression facilitates formation of small atypical glands with features of cancer, which increases in number with serial grafting. A pathologist determined the incidence of normal, hyperplasia, PIN and adenocarcinoma in all specimens in a blinded fashion by analyzing H&E and CK-14 staining of paraffin-embedded wild-type and PSMA-transgenic tissue recombinants. Only PSMA-transgenic tissue recombinants displayed small atypical glands with features of adenocarcinoma. The number of these small atypical glands with features of adenocarcinoma increases with serial grafting of the tissue recombinants. The Fisher’s exact test was used to analyze the incidence of PIN and foci with features of adenocarcinoma in wild-type and PSMA-transgenic tissue recombinants. The Jonckheere-Terpstra test was used to determine whether there is histopathological progression with serial grafting of the tissue recombinants.

Epithelium Normal Hyperplasia PIN Small atypical
foci with
features of
adenocarcinoma
8 wks Wild-type 1/9 (11%) 1/9 (11%) 7/9 (78%) 0/9 (0%)
PSMA+ 0/23 (0%) 0/23 (0%) 22/23 (96%) 1/23 (4%)
16 wks Wild-type 0/11 (0%) 4/11 (36%) 7/11 (64%) 0/11 (0%)
PSMA+ 0/23 (0%) 0/23 (0%) 16/23 (70%) 7/23 (30%)
24 wks Wild-type 2/19 (10.5%) 2/19 (10.5%) 15/19 (79%) 0/19 (0%)
PSMA+ 0/26 (0%) 1/26 (4%) 13/26 (50%) 12/26 (46%)