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. Author manuscript; available in PMC: 2010 Aug 18.
Published in final edited form as: Biochemistry. 2009 Aug 18;48(32):7584–7594. doi: 10.1021/bi9009264

Figure 7.

Figure 7

pH-dependent formation of the insertion-competent state of the T-domain (see text for details). Insertion is promoted by anionic lipids (75PC:25PG, red and 25PC:75PG, blue) and no insertion is observed in 90PC:10PG membrane (green), which is confirmed by topology experiments (Table 1). The formation of insertion-competent state is a result of a pH-dependent transition, distinct from the one resulting in the formation of membrane-competent state (compare to titration profiles in Fig. 3).