Skip to main content
. Author manuscript; available in PMC: 2010 Jul 28.
Published in final edited form as: Biochemistry. 2009 Jul 28;48(29):6876–6886. doi: 10.1021/bi900066b

Figure 3. Expression levels of genes induced or repressed in macrophage and osteoclast cells in response to treatment with soluble dephos-BSP relative to native BSP.

Figure 3

Genes with increased expression (Induced) or with decreased expression (Repressed) are presented. (A) Expression levels of genes induced or repressed in macrophage cells after treatment with dephos-BSP relative to native BSP. Induced genes relative expression. LKLF: lung Kruppel-like factor; IL-lRA: interleukin 1 receptor antagonist; ATF3: cAMP-dependent transcription factor 3; EGRl: early growth response protein 1; AP-1: transcription factor AP-l; c-myc: c-myc proto-oncogene; MIP2-α: macrophage inflamatory protein 2 alpha; PD1C: phosphodiesterase 1 C; LAMA3: laminin alpha 3 subunit precursor; PLCg: phospholipase C gamma; OSIP: oxidative stress-induced protein mRNA; GNRP: G-alpha-13 guanine nucleotide regulatory protein; mA TF4: activating transcription factor 4; Lb2: laminin B2 subunit. Decreased genes relative expression. CCNDl; CYL-l: Gl/S-specific cyclin Dl; ETA: 14-3-3 protein eta; GRG: related to Drosophila groucho gene; CD44P: CD44 antigen precursor; ITGBl: integrin beta 1; GRP78: 78-kDa glucose regulated protein; EPIM: epimorphin; DNARLF: MCM5 DNA replication licensing factor; PLA2: phospholipase A2; MAP3K7: mitogen-activated protein kinase 7; HR21spA; involved in DNA double-strand break repair; AA T2: alpha-I-antitrypsin 1–2 precursor.

(B) Expression levels of genes induced or repressed in osteoclast cells after treatment with dephos-BSP relative to native BSP. Induced genes relative expression: MIPIA: macrophage inflamatory protein 1 alpha; Act 2: macrophage inflamatory protein 1 beta; EGR1: early growth response protein 1; TTP: tristetraproline; CXN26: connexin 26; TFAP-1: transcription factor AP-l; MCP3: monotype chemoattractant protein 3; LKLF: lung Kruppel-like factor; PPO: piml proto-oncogene; GPCRLH: G protein-coupled receptor LCRI homolog; apo-EP: apolipoprotein E precursor; IL1RA: interleukin 1 receptor antagonist; c-myc: c-myc proto-oncogene; PLPre: plasminogen precursor. Repressed genes relative expression: Dvl2: dishevelled tissue polarity protein; 58kDI: 58-kDa inhibitor of RNA-activated protein kinase; PTLP: phospholipid transfer protein precursor; GRCSG: glutamate receptor channel subunit gamma; IL-2Ry: interleukin-2 receptor gamma subunit; cFFms: c-Fms proto-oncogene; CD147: cd147 antigen; CDLC1: cytoplasmid dynein light chain; CCP: cystatin c precursor; GNBP: guanine nucleotide binding protein; GM-CSF-R: granulocyte-macrophage cst receptor; ROX: basic helix-loop-helix leucine zipper protein rox; ETA: 14-3-3 protein eta; HSP86: heat shock 86-kDa protein; BKLF: CACCC Box- binding protein BKLF; GRG: related to Drosophila groucho gene.