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. Author manuscript; available in PMC: 2010 Jul 28.
Published in final edited form as: Biochemistry. 2009 Jul 28;48(29):6876–6886. doi: 10.1021/bi900066b

Figure 6. Type I collagen telopeptide ELISA assay in the media, and the TRAP activity of calvarial bone cultures stimulated to resorb by PTH in the absence and presence of BSP forms and GRDGS peptide.

Figure 6

Figure 6

Panel A: Type I collagen telopeptide release in to the media. Statistical two sample Student’s t test indicated that released collogen fragment was statistically significant and different for control versus PTH (p < 0.0001), control versus PTH + native BSP (p < 0.001), control versus PTH + dephosphorylated BSP (p < 0.003), PTH versus PTH + native BSP (p < 0.1), PTH versus PTH + dephosphorylated BSP (p< 0.001), and PTH versus PTH + GRGDS peptide (p < 0.05).

Panel B: TRAP activity of calvarial bone cellular components. Statistical two sample Student’s t test indicated that TRAP activity was statistically significant and different for control versus PTH (p < 0.001), control versus PTH + native BSP (p < 0.001), control versus PTH + dephosphorylated BSP (p = 0.003), PTH versus PTH + native BSP (p < 0.01), PTH versus PTH + dephosphorylated BSP (p = 0.03), and PTH versus PTH + GRGDS peptide (p < 0.05).