Skip to main content
. Author manuscript; available in PMC: 2010 Jun 1.
Published in final edited form as: Osteoporos Int. 2008 Oct 2;20(6):923–933. doi: 10.1007/s00198-008-0763-3

Table 4.

The association of BMD and bone turnover markers with current and long-term glycemic control in 75 premenopausal women with type 1 diabetes

Current
HbA1c (%)
10-year mean
Total GHb (%)
BMD (g/cm2) at Bone Sitesa
n=75
Heel
Unadjusted −0.016 (0.006)* −0.015 (0.005)*
Adjusted −0.014 (0.005)* −0.013 (0.005)*
Forearm
Unadjusted −0.012 (0.003)* −0.009 (0.003)*
Adjusted −0.010 (0.003)* −0.006 (0.002)*
n=19
Total Hip −0.037 (0.015)* −0.043 (0.016)*
Femoral Neck −0.040 (0.017)* −0.053 (0.017)*
Spine −0.022 (0.019) −0.021 (0.021)
Bone Turnover Markersa
n=75
Osteocalcin (nmol/L)
Unadjusted −0.03 (0.02) −0.01 (0.02)
Adjusted −0.04 (0.02)* −0.01 (0.02)
NTx (nmol BCE/L)
Unadjusted −0.1 (0.2) −0.1 (0.2)
Adjusted −0.5 (0.2)* −0.3 (0.2)
Uncoupling Index (1 Z-score)
Unadjusted −0.1 (0.1) −0.1 (0.1)
Adjusted 0.1 (0.1) 0.0 (0.1)

Data are regression coefficients (SEs) for associations with glycemic control HbA1c, hemoglobin A1c; GHb, glycosylated hemoglobin; BCE, bone collagen equivalent

*

p<0.05

a
Final models adjusted for:
  1. Heel/forearm BMD: age, BMI, energy expenditure (HbA1c), history of smoking (GHb)
  2. Osteocalcin: age (HbA1c), waist-to-hip ratio, weight change in last year (GHb), history of smoking, menstrual cycle length, years since menarche
  3. NTx: weight change in last year (HbA1c), history of smoking, years since menarche, medical conditions associated with BMD, time in menstrual cycle (HbA1c)
  4. Index: age, waist-to-hip ratio, weight change in last year (HbA1c), alcohol consumption (GHb), history of hormone use (HbA1c), menstrual cycle length (HbA1c), month of year (HbA1c)
  5. GHb: number of blood samples used to calculate mean GHb