Table 1.

NMR data for largamide A (1) in DMF-d₇ (500 MHz)

Unit	C/H no.	δH (J in Hz)	δC, mult.	HMBCa
Leu	1		172.0, qC
	2	4.67, ddd (10.0, 9.5, 4.5)	49.8, CH
	3	1.70, m	40.9, CH2	2, 4
		1.49, m
	4	1.58, m	24.8, CH
	5	0.86, d (6.5)	23.6, CH3	3, 4, 6
	6	0.89, d (6.5)	21.7, CH3	3, 4, 5
	NH	7.62, d (9.5)		1 (Glu)
Glu	1		171.6, qC
	2	4.51, ddd (9.5, 9.0, 4.5)	53.0, CH	1, 4
	3	2.53, m	27.0, CH2	5
		2.14, m
	4	2.54, m	31.1, CH2	5
		2.42, m
	5		175.2, qC
	OH	not observed
	NH	7.54, d (9.0)		1 (Abu)
Abu	1		164.0, qC
	2		130.9, qC
	3	6.54, q (7.0)	129.1, CH	1
	4	1.76, d (7.0)	12.7, CH3	1, 2, 3
	NH	10.16, s		1 (Ala)
Ala	1		175.8, qC
	2	4.33, qd (6.5, 2.5)	50.7, CH	1, 1 (Thr)
	3	1.38, d (6.5)	16.8, CH3	1, 2
	NH	8.83, d (2.5)		1 (Thr)
Thr	1		170.3, qC
	2	4.74, dd (8.5, 3.0)	55.8, CH	1, 1 (Tyr)
	3	5.37, qd (6.3, 3.0)	72.9, CH	4
	4	1.18, d (6.3)	16.1, CH3	2, 3
	NH	7.90, d (8.5)		1 (Tyr)
Tyr	1		172.7, qC
	2	4.78, ddd (10.0, 9.5, 4.5)	55.9, CH	1, 4
	3	3.07, dd (−14.0, 4.5)	38.1, CH2	2, 4, 5/9
		2.82, dd (−14.0, 10.0)
	4		128.6, qC
	5/9	7.12, d (8.5)	131.1, CH	7
	6/8	6.70, d (8.5)	115.6, CH	7
	7		157.1, qC
	OH	9.34, s		7
	NH	8.10, br		1 (Val)
Val	1		171.9, qC
	2	4.29, dd (9.0, 7.0)	59.3, CH	1, 3, 4, 5
	3	2.01, m	31.6, CH	2, 4, 5
	4	0.75, d (6.5)	19.7, CH3	2, 3
	5	0.72, d (6.5)	18.4, CH3	2, 3
	NH	7.26, brd (7.0)		1 (Tig)
Tig	1		169.3, qC
	2		132.7, qC
	3	6.42, qq (7.0, 1.0)	130.4, CH	1
	4	1.71, br d (7.0)	13.8, CH3	2, 3
	5	1.80, br s	12.5, CH3	1, 2, 3

^aProtons showing long-range correlation with indicated carbon.