Table 1.

A subset of indiscriminate, highly-connected biomarker nodes and their disease targets

Biomarker	Diseases
Plasma
AZGP1	Cardiac hypertrophy, Spinal cord injury, Idiopathic cardiomyopathy, Idiopathic thrombocytopenic purpura, E. coli infection of the CNS, Hypercholesterolemia, Clear cell carcinoma of kidney, Hypertrophy, Glioblastoma, Adenoma of small intestine, Thrombocytopenia, Carcinoma in situ of small intestine, AML, Huntington’s disease, Porcine nephropathy, Allergic asthma, Cirrhosis of liver, Adenovirus infection, Squamous cell carcinoma, Duchenne muscular dystrophy
CD46	Malignant neoplasm of prostate, Complex dental cavity, Fracture of bone, MODY, Dermatomyositis, Bacterial infection, Clear cell carcinoma of kidney, Spinal cord injury, Status epilepticus, Senescence, Fracture of femur, Barrett’s ulcer of esophagus, Rheumatoid arthritis, Urothelial carcinoma, Astrocytoma, Glioblastoma, Congestive cardiomyopathy, Obesity, Lung transplant rejection
LAMA2	Breast cancer, Dermatomyositis, Malignant neoplasm of stomach, Acute lung injury, Malignant melanoma, Glioblastoma, Adenovirus infection, Duchenne muscular dystrophy, Acute promyelocytic leukemia, Senescence, Barrett’s ulcer of esophagus, AML, Hypercholesterolemia, Hepatic lipidosis, Acute pancreatitis, Idiopathic thrombocytopenic purpura, Porcine nephropathy, Urothelial carcinoma, AIDS
Urine
AKR1C1	Acute lung injury, Acute arthritis, Essential thrombocythemia, Ulcerative colitis, Lung transplant rejection, Malignant melanoma, Carcinoma in situ of small intestine, Dehydration, Adenoma of small intestine, Bacterial infection, Glioblastoma, Oligodendroglioma, Urothelial carcinoma, Progeria syndrome, Atrial fibrillation, Huntington’s disease, SARS, Adenocarcinoma of lung
PRG4	Multiple benign melanocytic nevi, Urothelial carcinoma, Type 2 diabetes mellitus, Actinic keratosis, Adenocarcinoma of lung, Thrombocytopenia, Acute myeloid leukemia, Huntington’s disease, Cardiomyopathy, Ventilator-associated lung injury, Macular degeneration, Congestive cardiomyopathy, Polycystic ovary syndrome, Dermatomyositis, Adenovirus infection, Acute pancreatitis
AQP2G4	Clear cell carcinoma of kidney, Dermatomyositis, Breast cancer, Duchenne muscular dystrophy, Hepatocellular carcinoma, Bacterial infection, Barrett’s ulcer of esophagus, Helicobacter pylori GI infection, Macular degeneration, MODY, Urothelial carcinoma, AML, Crohn’s disease, Ulcerative colitis, Epithelial proliferation