Table 3.

Metal dependence of the enzyme catalytic activities.

Enzyme class	Zn	Mn	Fe2+	Fe3+	Cu	Co	Ni	Mo
Oxidoreductases	1	1	33	6	6	1	1	7
Transferases	1	5
Hydrolases	17	4	1a	1			1
Lyases	6	2	1	1		1
Isomerases		2				5
Ligases

The numbers of enzymes with particular transition metals as catalytic cofactors are from the MACiE database [179,180], and its recently described Metal-MACiE supplement [181,182], see text for details.

^a – Peptide deformylase, where the Fe atom is functionally replaceable by Co, Ni or Zn [185].