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. 2009 Sep 2;8:38. doi: 10.1186/1476-511X-8-38

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Copyright © 2009 Zavvarreza et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fatty acids decreases Intracellular total cholesterol (TC), free cholesterol (FC) and esterified cholesterol (EC) levels in THP-1 derived foam cells. THP-1 derived macrophages were cholesterol-loaded with Ac-LDL (50 μg/mL) for 48 hours. Wy14643 (50 μmol/L) and Sandoz58-035 (5 μM) was added 24 hours before cholesterol-loading and thereafter every 24 hours. TC and FC were enzymatically determined and CE were calculated as the difference between TC and FC. Results are the mean ± SD of triplicate determinations, representative of 3 independent experiments. Statistically significant differences between treatments are indicated by one-way ANOVA followed by Tukey multicomparison test. Compared with controls all treatments were significant (p ≤ 0.05).