Table 6.
Type I error in the disease association study.
Disease model parameters | SS* | MB | HB | MDL | GAB | GPG | GPF |
DAF = 5% – 15%, GRR1 = 3 | 0.26 | 0.20 | 0.17 | 0.16 | 0.17 | 0.13 | 0.13 |
DAF = 5% – 15%, GRR1 = 5 | 0.32 | 0.24 | 0.21 | 0.20 | 0.22 | 0.16 | 0.17 |
DAF = 20% – 30%, GRR1 = 3 | 0.29 | 0.21 | 0.18 | 0.17 | 0.19 | 0.14 | 0.15 |
DAF = 20% – 30%, GRR1 = 5 | 0.34 | 0.25 | 0.22 | 0.22 | 0.23 | 0.17 | 0.19 |
Chi-square tests have been performed at 0.05 level of significance, on 250 sets of 50/50 case-control samples. Each entry depicts the proportion of blocks that have been falsely recognized as trait-associated to all the blocks that do not include the trait locus. * Method of single site test. See Table 1 for method abbreviations.