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. 2009 Jul 1;284(35):23558–23563. doi: 10.1074/jbc.M109.023358

FIGURE 3.

FIGURE 3.

DRS has no effect on the gating properties of DmNav1. A, currents induced by a test pulse (50 ms) ranging from −80 to 0 mV (5 mV increments) of oocytes expressing DmNav1/TipE. Left panel, control; right panel, 5 μm DRS. B, conductance-voltage relationship of DmNav1 (open circles; V0.5 = −19.1 ± 0.5 mV, K = 5.5 ± 0.4), and in the presence of 5 μm DRS (black circles; V0.5 = −20.7 ± 0.7 mV, K = 5.5 ± 0.5). G/Gmax, relative conductance. C, steady-state fast inactivation was determined from holding potential of −80 mV using a series of 50 ms prepulses from −80 to −0 mV in 5 mV increments prior to the test pulse (50 ms) to −10 mV. The steady-state inactivation of DmNav1 (open circles) fits a Boltzmann function with V0.5 = −45.6 ± 0.1 mV (k = 3.4 ± 0.1), and in the presence of 5 μm DRS (black circles) V0.5 = −44.7 ± 0.1 mV (k = 4.3 ± 0.1). I/Imax, relative current.