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Inhibition of MBP-MtHPS. A, initial step and corresponding geranylgeran-15-yl+ diphosphate transition state of class II cyclization reaction; B, effect of 15-aza-GGPP (7a; ○) and 15-aza-GGSPP (7b; □), with structures shown (inset), on MBP-MtHPS activity.
