Fig. 12.

Dose–response functions after alteration of a single parameter, k₋₆. The steady dose–response curve is shifted to higher uptakes, the saturation amplitude is reduced and the curve increases over a narrower range of uptakes (a). The fall of the model receptor-potential becomes faster (b), whereas its rise slows down (c). The changes are indicated by arrows. Dots experimental data (see legend Fig. 1a). The dashed line in (a) shows the adjusted computer reference of the data