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Novel signal transduction cross-talk between AT1 and AT2 in VSMCs. The Rho/Rhokinase cascade inhibition by the AT2 receptor via the “triple-twist” theory involving SHP-1, CK2 and SLK not only inhibits AT1-induced vascular contraction, but also likely inhibits VSMC hypertrophy and migration. In addition, CK2 may be activated through the AT1 receptor, and AT2-activated SHP-1 has been shown to directly inactivate EGFR to inhibit AT1-activated hypertrophic signal transduction.
