Figure 2.
CRP caused hypertension in rats. (A) Systolic blood pressure was monitored from the beginning of the study using the tail-cuff method. Rats injected with AAV-hCRP had significantly increased blood pressure beginning 2 months after gene delivery (P =0.000). Hemodynamic parameters were increased by CRP gene transfer. (B) CRP gene delivery increased mean aortic pressure (P =0.001). (C) CRP gene delivery increased maximum left ventricular pressure (P =0.004). (D) CRP gene delivery increased arterial elastance (P =0.000). Data represent mean ± SEM of 6 to 8 rats/group. * P < 0.05 vs. control group.