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NO biosynthesis was decreased by CRP gene delivery. (A) Endothelial-dependent relaxation to acetylcholine in aortic segments was impaired by CRP gene transfer. (B) CRP gene delivery decreased serum NO concentration. (C) CRP gene delivery decreased urine cGMP excretion. Data are presented as the mean ± SEM of 6 to 8 rats/group. * P < 0.05 vs. control group.
