Table 1.

Cardiac function in heart-specific Na,K-β₁ knockout mice

	4 months		10 months		13–14 months
	WT	KO	WT	KO	WT	KO
	(n=3)	(n=5)	(n=4)	(n=5)	(n=7)	(n=7)
Body weight, g	30.3 ± 4.2	29.4 ± 2.2	31.7 ± 2.5	36.4 ± 1.2	37.0 ± 2.9	37.5 ± 1.7
Heart weight, mg	143.7 ± 16.0	180.8 ± 23.7	159.2 ± 12.7	188.3 ± 7.3	162.3 ± 8.5	188.7 ± 7.7*
Tibia length, mm	17.9 ± 0.1	18.0 ± 0.1	19.2 ± 0.6	19.5 ± 0.5	18.8 ± 0.1	19.3 ± 0.2
HW/BW, mg/g	4.8 ± 0.2	5.7 ± 0.4	5.0 ± 0.1	5.2 ± 0.2	4.5 ± 0.3	5.1 ± 0.2*
HW/TL, mg/mm	8.0 ± 0.8	8.8 ± 1.2	8.3 ± 0.4	9.7 ± 0.4*	8.6 ± 0.5	9.8 ± 0.4*
Left ventricular mass	81 ± 7	102 ± 16	118 ± 7	121 ± 11	113 ± 9	117 ± 14
PWT, mm	0.63 ± 0.04	0.73 ± 0.06	0.68 ± 0.01	0.75 ± 0.04	0.71 ± 0.02	0.68 ± 0.03
VST, mm	0.59 ± 0.02	0.71 ± 0.03	0.71 ± 0.03	0.79 ± 0.04	0.73 ± 0.02	0.72 ± 0.05
EDD, mm	3.97 ± 0.20	3.94 ± 0.15	4.44 ± 0.15	4.16 ± 0.10	4.20 ± 0.14	4.34 ± 0.17
ESD, mm	2.73 ± 0.12	2.68 ± 0.12	3.00 ± 0.09	2.70 ± 0.11	2.81 ± 0.13	3.24 ± 0.13*
LVFS, %	31.0 ± 0.8	32.0 ± 1.6	32.4 ± 1.4	35.1 ± 2.3	33.0 ± 1.7	25.3 ± 0.8#
Vcf, mm/s	5.27 ± 0.26	5.53 ± 0.45	6.54 ± 0.30	7.29 ± 0.40	6.61 ± 0.48	4.59 ± 0.17#
LVEF, %	65.5 ± 1.3	66.5 ± 2.4	68.5 ± 2.3	71.0 ± 2.3	66.4 ± 2.5	56.7 ± 1.8#

Values are SE of the Mean.

^#p<0.01

^*p<0.05