Figure 3. Prophylactic blockade of IL-10 signaling increases survival of WNV-infected mice.

A group of C57BL6 mice were i.p. administered anti-IL-10 receptor monoclonal antibody (aIL-10r mAb) or isotype-matched IgG control antibody one day before challenge with WNV. (A), Viral load was measured in blood on day 3 p.i. by Q-PCR (p = 0.07, LD₅₀, i.p..); (B–C), Kaplan-Meier survival analysis showed significant differences between the aIL-10r mAb and isotype-matched IgG treated group. (B, i.p. inoculation [LD₅₀], n = 17/group, data were pooled from 3 independent experiments; C, footpad inoculation [100 pfu], n = 10/group). *p<0.05, compared to control mice.