Figure 1. Splenectomy prevents Jak2^V617F -driven polycythemia in mice.

(A) 6 week old female C57Bl/6 mice underwent splenectomy (SPL, ▪) or sham (SH, □) operations. (B) 6 week old female Balb/c mice underwent splenectomy (SPL, ♦) or sham (SH, ◊) operations. Followed by 2 week recovery, irradiation and injection of Jak2^V617F -transduced bone marrow cells from congenic donors. Hematocrit was measured weekly until disease was maximal in sham-operated mice (n = 12/group, error bars indicate SD). Open symbols = sham operated; filled symbols = splenectomy. * indicates p<0.05 compared to SH operated mice.