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. Author manuscript; available in PMC: 2010 Apr 1.
Published in final edited form as: Circ Cardiovasc Genet. 2009 Feb 12;2(2):134–141. doi: 10.1161/CIRCGENETICS.108.825273

Figure 2.

Figure 2

Genetic Context of Loci with Genome-Wide Significant Associations with Fibrinogen Data are presented that map each SNP according to its physical location at each of the 5 loci, as well a plot of the P-values in relation to the distance from known recombination hotspots according to HapMap. Top panel: genes from RefSeq release 25 are shown. Only one isoform is shown when multiple splicing variants are known. Lower panel: SNPs are shown according to their physical location and P-values (red dots). Also shown is the genetic distance in cM from the lowest P-value SNP (light grey line) along with the position of recombination hotspots (light grey vertical bars). Recombination rates and hotspots are based on HapMap data, as described by McVean et al.32.

The IL6R region is shown in Figure 2-A, the CPS1 region in Figure 2-B, the fibrinogen gene cluster (4q32.1) in Figure 3-C, the SLC22A5, SLC22A4, IRF1 locus (5q31.1) in Figure 2-D and the CD300LF, SLC9A3R1, NAT9 locus in Figure 2-E.