Table 3.

Relationship of SNPs of Genome-Wide Significance to Fibrinogen with CRP Levels and Relationship of SNPs of Genome-Wide Significance to CRP with Fibrinogen Levels

Nearest Candidate Gene(s)	SNPs	Association with Fibrinogen		Association with CRP*
		Beta-Coefficient	P-value	Beta-Coefficient	P-value
Genes/SNPs Associated with Fibrinogen at Genome-wide Significance
IL6R	rs8192284	-5.299	1.80×10-11	-0.109	1.04×10-22
CPS1	rs7422339	-4.843	8.82×10-09	0.004	0.750
FGB, FGA, FGG	rs6056	12.940	8.04×10-39	-0.002	0.867
SLC22A5, SLC22A4, IRF1	rs1016988	-6.839	1.24×10-12	-0.022	0.112
CD300LF, SLC9A3R1, NAT9	rs10512597	-6.450	7.72×10-11	-0.046	9.85×10-04
Genes/SNPs Associated with CRP* at Genome-wide Significance
IL6R	rs8192284	-5.299	1.80×10-11	-0.109	1.04×10-22
CRP	rs3091244	-0.111	0.890	0.224	7.10×10-88
LEPR	rs1892534	-2.067	0.009	-0.148	2.24×10-40
GCKR	rs780094	2.410	0.002	0.131	2.74×10-32
Gene Desert	rs10778213	1.998	0.010	-0.089	3.75×10-16
HNF1A	rs7310409	-0.587	0.462	-0.176	9.61×10-56
APOE	rs769449	-1.337	0.251	-0.270	5.98×10-57

^*CRP was log-transformed

Abbreviations

CRP = C-reactive protein

LEPR = leptin receptor protein

GCKR = glucokinase regulatory protein

HNF1 = hepatic nuclear factor-1 (transcription factor 1, hepatic [TCF1])

APOE = apolipoprotein E